He's a star of screens both big and small, but Patrick Dempsey has spent enough time in obscurity to never take the success for granted.
The Grey's Anatomy star might be scorching hot in more than 60 countries now, but if he's as anywhere near as ego-obsessed and as full of himself as some of his TV and movie contemporaries, he's doing a really good job of hiding it.
In almost every interview he's done since Grey's Anatomy became a global hit three years ago, Patrick Dempsey has presented himself as genuinely thankful for the role of stethoscope-swinging sex symbol Dr. Derek "McDreamy" Shepherd.
Before Grey's Anatomy came along, Dempsey was wallowing in mediocrity, and plagued by self-doubt. According to the Melbourne Herald-Sun, he actually kept telling himself, depressingly, "I'm ugly, I'm no good, I'm a has-been."
The actor's spirits flagged when he auditioned for, but barely missed out, on a role in the current FOX hit House. Dempsey was called back as many as 15 times by producers who were divided over his suitability for the role.

Patrick Dempsey tested for the role of Grey's Anatomy's Derek Shepherd only after Rob Lowe (The West Wing, Brothers & Sisters) turned it down.
Dempsey also had to contend with dyslexia when trying to read script pages at audition. He tried to memorize lines because he struggled to read them off the page. He couldn't focus and, at certain times, he could hardly speak.
Patrick was convinced that Grey's Anatomy creator Shonda Rhimes, sitting quietly at the back of the audition room, hated him.
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