We knew that Isaiah Washington originally tried out for the role of Dr. Derek Shepherd during the casting of Grey's Anatomy before being offered the role of Dr. Preston Burke. But it turns out he's not the only well-known (and handsome) actor to have been considered for the McDreamy role that went to Patrick Dempsey and revitalized his career.
Former "Brat Pack" member and West Wing star Rob Lowe is said to have been in serious talks about playing Dr. Shepherd - and the actor himself withdrew from consideration. In a recent interview, he said it was the first time in his career that he chose wrong.
Crazy stuff. The only wrong choice Patrick made (in his own words) was Addison over Meredith in Season 2, but that isn't really the same.
There could never be another Derek, which Dempsey portrays to perfection and displays wonderful chemistry with Ellen Pompeo. But you have to admit that Rob Lowe has certain McDreamy qualities. He recently joined the cast of ABC's Brothers & Sisters, however, so you can catch him there!






December 7th, 2006 10:15 AM
RL may have chose wrong but we got the right man--no one but Patrick but could be our McDreamy!
December 7th, 2006 11:00 AM
Patrick is perfect and his chemistry with Ellen is amazing!
December 7th, 2006 11:06 AM
"The only wrong choice Patrick made (in his own words) was Addison over Meredith in Season 2, but that isn't really the same."
I love Patrick.
December 7th, 2006 12:36 PM
Wow -- I just can't picture Rob Lowe as Derek. Patrick Dempsey just owns that character. I just don't think it would have been the same if Rob Lowe had been cast.
December 7th, 2006 6:35 PM
I am so glad Patrick got the part. I don't think Rob Lowe would have developed the character as good as Patrick did. The chemistry he has with Ellen is very rare.
December 7th, 2006 7:12 PM
Thank GOD Rob Lowe backed out! I can not even imagine anyone but our dear Patrick playing the roll of Derrick. The way he looks at Meredith.... it just wouldn't be the same.
December 7th, 2006 9:14 PM
I too am glad that Patrick Dempsey ended up with the role. However, as a West Wing fan, I must admit that it is ironic that on the pilot for the West Wing Sam/Rob sleeps with a woman only to discover the next day that she is a call girl. Given the plot of the pilot for Grey's Anatomy, that strikes me as highly amusing.
December 10th, 2006 10:21 PM
Whatever, Rob Lowe is an amazing actor. Sure, it would've been different, but who's to know if he wouldn't have "owned" the character of Derek as Patrick Dempsey does. They're both phenomenal.
January 7th, 2007 6:55 PM
derik is one hot piece of pie!! i love his character!
January 14th, 2007 5:05 PM
well im not saying rob lowe wouldnt be good at it, but the mcdreamy look wouldnt exist. that look is the very reason patrick dempsey is amazing at the part. no one could pull that look off anymore and the finale of season 2 with "stop looking at me" would never have meant the same as it did with patrick. i love patrick i hope he stays on the show as long as the show stays on. whatta great guy!