"You just have to know. And when you don't know? No one can fault you for it. You do what you can, when you can, while you can. When you can't, you can't."

-- Dr. Bailey

While it may be challenging to wrap one's brain around that quote from Miranda, it seems to sum up last night's episode, "Begin the Begin," perfectly. Not knowing what to make of what they've learned, or where they're going with each passing day, is the central theme.

Interns, surgeons and patients alike struggle with personal and professional dilemmas. Work, sex, marriage, relationships, pregnancy, Alzheimer's -- collectively, it's not an easy week at Seattle Grace.

You can read our brief episode guide by following the link above, and also check out our full list of quotes. If you missed it, or are looking for a recap, this is a good way to re-live the episode where Addison's passive-aggressive rage hits its peak, George identifies with a troubled young patient, and we're first introduced to a charming man named Denny.